{"title":"维生素对尼日利亚2型糖尿病患者丙二醛和谷胱甘肽水平的影响","authors":"N. Ifeoma, C. Obioma, C. Chinyere","doi":"10.5580/538","DOIUrl":null,"url":null,"abstract":"The effect of modest supplementation of vitamin E (α-tocopherol) on lipid peroxidation product, malondialdehyde (MDA), and reduced glutathione (GSH), was investigated in type 2 diabetic Nigerian patients. Written and informed consent to participate in this study was obtained from 80 type 2 diabetic patients. 50 randomly selected type 2 diabetic patients were supplemented with vitamin E capsule orally (1000 i.u / day ) and 30 age-matched patients to placebo for 2 months. Fasting blood was collected from each patient before and after vitamin E or placebo supplementation. Levels of Reduced glutathione (GSH ) and malondialdehyde (MDA) were determined. Hyperglycemia correlated with reduced blood GSH and increased malondialdehyde levels in type 2 diabetes. Vitamin E supplementation significantly increased GSH levels ( P<0.05 ) and lowered MDA levels ( p<0.05 ) which are markers of oxidative stress and this may reduce the risk of microvascular and macrovascular complications associated with diabetes mellitus.","PeriodicalId":339404,"journal":{"name":"The Internet Journal of Nutrition and Wellness","volume":"16 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"14","resultStr":"{\"title\":\"Effect Of Vitamin On Malondialdehyde And Glutathione Levels In Type 2 Diabetic Nigerians\",\"authors\":\"N. Ifeoma, C. Obioma, C. Chinyere\",\"doi\":\"10.5580/538\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The effect of modest supplementation of vitamin E (α-tocopherol) on lipid peroxidation product, malondialdehyde (MDA), and reduced glutathione (GSH), was investigated in type 2 diabetic Nigerian patients. Written and informed consent to participate in this study was obtained from 80 type 2 diabetic patients. 50 randomly selected type 2 diabetic patients were supplemented with vitamin E capsule orally (1000 i.u / day ) and 30 age-matched patients to placebo for 2 months. Fasting blood was collected from each patient before and after vitamin E or placebo supplementation. Levels of Reduced glutathione (GSH ) and malondialdehyde (MDA) were determined. Hyperglycemia correlated with reduced blood GSH and increased malondialdehyde levels in type 2 diabetes. Vitamin E supplementation significantly increased GSH levels ( P<0.05 ) and lowered MDA levels ( p<0.05 ) which are markers of oxidative stress and this may reduce the risk of microvascular and macrovascular complications associated with diabetes mellitus.\",\"PeriodicalId\":339404,\"journal\":{\"name\":\"The Internet Journal of Nutrition and Wellness\",\"volume\":\"16 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"14\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet Journal of Nutrition and Wellness\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5580/538\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet Journal of Nutrition and Wellness","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/538","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 14
摘要
研究了适度补充维生素E (α-生育酚)对尼日利亚2型糖尿病患者脂质过氧化产物丙二醛(MDA)和还原性谷胱甘肽(GSH)的影响。80名2型糖尿病患者获得了参与本研究的书面和知情同意书。随机选择50例2型糖尿病患者口服维生素E胶囊(1000 iu /天)，30例年龄匹配的患者口服安慰剂2个月。在补充维生素E或安慰剂之前和之后采集每位患者的空腹血。测定还原型谷胱甘肽(GSH)和丙二醛(MDA)水平。高血糖与2型糖尿病患者血液GSH降低和丙二醛水平升高相关。补充维生素E可显著提高GSH水平(P<0.05)，降低氧化应激标志物丙二醛水平(P<0.05)，从而降低糖尿病相关微血管和大血管并发症的风险。
Effect Of Vitamin On Malondialdehyde And Glutathione Levels In Type 2 Diabetic Nigerians
The effect of modest supplementation of vitamin E (α-tocopherol) on lipid peroxidation product, malondialdehyde (MDA), and reduced glutathione (GSH), was investigated in type 2 diabetic Nigerian patients. Written and informed consent to participate in this study was obtained from 80 type 2 diabetic patients. 50 randomly selected type 2 diabetic patients were supplemented with vitamin E capsule orally (1000 i.u / day ) and 30 age-matched patients to placebo for 2 months. Fasting blood was collected from each patient before and after vitamin E or placebo supplementation. Levels of Reduced glutathione (GSH ) and malondialdehyde (MDA) were determined. Hyperglycemia correlated with reduced blood GSH and increased malondialdehyde levels in type 2 diabetes. Vitamin E supplementation significantly increased GSH levels ( P<0.05 ) and lowered MDA levels ( p<0.05 ) which are markers of oxidative stress and this may reduce the risk of microvascular and macrovascular complications associated with diabetes mellitus.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
