一些精神药物对长期灌喂乙醇大鼠离体肝脏消除乙醇的影响。

Acta physiologica Polonica Pub Date : 1990-11-01
G Rajtar, Z Kleinrok
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引用次数: 0

摘要

在4周的时间里,大鼠接受乙醇(EtOH)作为唯一的饮用液体,浓度在6%至20%之间。在EtOH停药后72小时内,大鼠给予地西泮(DZP)、丙咪嗪(IMI)或咖啡因(CAFF),每天两次,间隔12小时。在对这些大鼠肝脏进行的分离实验中,我们观察到DZP和IMI处理的大鼠肝脏从灌注液中消除EtOH的速率降低。CAFF没有改变EtOH的消除速率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of some psychotropic drugs on the ethanol elimination by the isolated liver of rats chronically fed with ethanol.

During a 4-week period the rats received ethanol (EtOH), as their only drinking fluid, in a concentration ranging from 6% to 20%. In the period of 72 hours after EtOH withdrawal the rats received diazepam (DZP), imipramine (IMI) or caffeine (CAFF) i.p. twice a day in a 12-hours interval. In the experiments carried out on the livers isolated from these rats, we observed the diminution of the rate of EtOH elimination from the perfusate by the livers of DZP and IMI treated rats. CAFF did not change the rate of EtOH elimination.

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