氯胺酮致家兔窒息性呼吸的布鲁尔-赫林反射。

Acta physiologica Polonica Pub Date : 1990-01-01
H Gromysz, W A Karczewski, A Kukwa, U Jernajczyk
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引用次数: 0

摘要

研究氯胺酮对氟烷麻醉、麻痹和人工通气家兔脊骨舌骨神经(第5神经分支)和双膈神经活动的影响。静脉注射氯胺酮可明显延长膈肌吸气放电(但不显著影响其幅度),并抑制髓舌骨肌的呼气活动。在这些条件下,肺中与体积相关的输入的消除(“无充气操作”)或收缩引起典型的呼吸停息模式。吸气高峰时对气管闭塞的反应是“经典的”。我们认为氯胺酮抑制了Vth神经运动核,而Vth神经运动核不仅是中枢吸气抑制神经元的重要组成部分,而且是迷走神经和中枢吸气“关闭”机制之间的“中继站”。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Breuer-Hering reflexes in ketamine-induced apneustic breathing in the rabbit.

The effects of ketamine on the activities of the mylohyoid nerve (a branch of the Vth nerve) and of both phrenic nerves were investigated in rabbits anaesthetized with halothane, paralyzed and artificially ventilated. Intravenous administration of ketamine elicited a marked prolongation of the phrenic inspiratory discharge (without significantly affecting its amplitude) and a depression of the mylohyoid expiratory activity. An elimination of the volume-related input from the lungs ("no-inflation manoeuvre") or deflation elicited under these conditions typical apneustic pattern of breathing. The response to tracheal occlusion at peak-inspiration was "classical". We conclude that ketamine inhibits the Vth nerve motor nucleus which is not only an important component of the central inspiratory-inhibitory neurones but also a "relay station" between the vagal and the central inspiratory "off-switch" mechanisms.

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