Efek analgesik ektrak daun trembesi (Samanea Saman (jacq.) Merr.) terhadap mencit putih (Mus musculus)Analgesic effect of trembesi leaf extract (Samanea saman (Jacq.) Merr.) on white mice (Mus musculus)

Introduction : Pain is an sensory and emotional unpleasant experience because of tissue damage. Secondary metabolites of flavonoids and steroids from Trembesi (Samanea saman (Jacq.) Merr.) leaf extract have a function as analgesics by inhibiting inflammatory mediators so the release of arachidonic acid and the action of the cyclooxygenase enzyme is blocked. This study aimed to analyzed the analgesic effect of Trembesi leaf extract on white mice (Mus musculus). Methods : This experimental laboratory study used a simple random sampling technique with 30 mice samples divided into 5 groups. Trembesi leaf extract used was dose of 25 mg/kgBW, 50 mg/ kgBW, 100 mg/kgBW, negative control CMC.Na 0.5%, and positive control Acetosal, given oral to each group, then induced pain with 1% acetic acid intraperitoneally. Number of stretching mice was observed every 5 minutes for 30 minutes, then the percentage of analgesic effectiveness was calculated by comparing the percentage of analgesic protection of the test group to the percentage of analgesic protection of the positive control group. Results : Trembesi leaf extract at a dose of 100 mg/kgBW gave a great analgesic effect, 76.62% compared to Trembesi leaf extract at a dose of 25 mg/kgBW (24.63%) and 50 mg/kgBW (49.34%). The significance value of the Kruskal Wallis test results is 0.001 so it can be interpreted that there is a significant difference in the analgesic effectiveness of Trembesi leaf extract between groups. Conclusion : There is an analgesic effect of Trembesi (Samanea saman (Jacq.) Merr.) leaf extract on white mice (Mus musculus).