Indah Sagitaisna Putri, Bastomy Eka Rezkita, Steven Irving, Akhmad Azmiardi
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引用次数: 0
摘要
醛糖还原酶基因多态性与糖尿病视网膜病变(DR)有关。研究数据来自PubMed和EMBASE。我们发现-106C > T单核苷酸多态性(SNP)。计算池优势比(OR)， 95% CI。纳入了9项研究。ALR2 106C > T基因多态性与T1DM患者发生DR的风险增加相关(C vs. T, OR = 2.07, p = 0.001;CC vs CT + TT, OR = 2.56, p = 0.005)。T等位基因和TT基因型与T1DM患者发生DR的风险降低相关(OR = 0.48, p = 0.0001和OR = 0.12, p = 0.0005)。综上所述，C等位基因和CC基因型可能是T1DM患者发生DR的危险因素，T等位基因和TT基因型可能是T1DM患者发生DR的保护因素。
The association Between ALR2 -106C>T Gene Polymorphisms and Diabetic Retinopathy Susceptibility In Diabetes Mellitus Patient: A Systematic Review and Meta-Analysis
Aldose reductase gene polymorphisms has been indicated to be associated with diabetic retinopathy (DR). The research data were from PubMed and EMBASE. We identified -106C > T single nucleotide polymorphism (SNP). Pool odds ratio (OR) with 95% CI were calculated. Nine studies were included. ALR2 106C > T gene polymorphisms was associated with the increased risk of DR in T1DM (C vs. T, OR = 2.07, p = 0.001; CC vs. CT + TT, OR = 2.56, p = 0.005). T allele and TT genotype were associated with decreased risk of DR in T1DM (OR = 0.48, p = 0.0001 and OR = 0.12, p = 0.0005). In conclusion, C allele and CC genotype may be a risk factor, while T allele and TT genotype may serve as protective factor for DR in T1DM patient.
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