[Evaluation of immunostimulation of sheep with Propionibacterium acnes strain CN 5936 in the prevention of listeriosis].

The purpose of this work was to observe and estimate immune reaction taking place in pregnant sheep and their progeny after applying immunomodulator being a formalized culture strain Propionibacterium acnes CN 5936 [PA]. This biological preparation was used in order to reduce the endemic form of listeriosis in a big flock of sheep. 15 pregnant sheep were vaccinated with PA 4 weeks before the date of delivery and later, the sheep's progeny at the age of 3 weeks. During that experiment immunological, clinical and breeding estimations were carried out. The results of the experiment allow to draw a conclusion that the PA immunomodulator causes a considerable increase in specific cell-mediated parametres in pregnant sheep. The above described experiment of modulating pregnant sheep and their progeny reduces considerably lambs' clinical symptoms and mortality caused by listeriosis. Moreover, this method of immunoprophylaxis positively affects lambs' weight increase.