Jiah Kim, Neha Chivukula Venkata, Gabriela A Hernandez Gonzalez, Nimish Khanna, A. Belmont
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Gene expression amplification by nuclear speckle association
Many active genes position near nuclear speckles. Kim et al. show that Hsp70 speckle association correlates with increased nascent transcripts. Live-cell imaging shows that increases in nascent Hsp70 transcripts strictly follow speckle association (∼0–2 min), suggesting that speckle association amplifies gene expression.
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