{"title":"各厂家0.9%氯化钠受控和非受控理化质量指标","authors":"A. Kasatkin, A. Nigmatullina, M. Kopytov","doi":"10.33920/med-06-2003-01","DOIUrl":null,"url":null,"abstract":"The article presents the results of studies of osmolality and pH of 0,9 % sodium chloride of various manufacturers. To obtain data on the pH value, the data used in the passports are used, and the indicators of its osmolality are de- termined using laboratory tests. 0,9 % sodium chloride from different manufacturers has different pH and osmolality. Knowing the actual values of physico-chemical parameters can increase the accuracy of the results of future clinical studies, which compare the pharmacokinetics and pharmacodynamics of modern plasma-substituting solutions and a solution of 0,9 % sodium chloride.","PeriodicalId":220616,"journal":{"name":"Novejshie zarubezhnye i otechestvennye lekarstvennye preparaty: farmakoterapija, farmakodinamika, farmakokinetika (Newest Foreign and Domestic Preparations: Pharmacotherapy, Pharmacodynamics, Pharmacokinetics)","volume":"203 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Controlled and uncontrolled physicochemical quality indicators of 0.9 % sodium chloride of various manufacturers\",\"authors\":\"A. Kasatkin, A. Nigmatullina, M. Kopytov\",\"doi\":\"10.33920/med-06-2003-01\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The article presents the results of studies of osmolality and pH of 0,9 % sodium chloride of various manufacturers. To obtain data on the pH value, the data used in the passports are used, and the indicators of its osmolality are de- termined using laboratory tests. 0,9 % sodium chloride from different manufacturers has different pH and osmolality. Knowing the actual values of physico-chemical parameters can increase the accuracy of the results of future clinical studies, which compare the pharmacokinetics and pharmacodynamics of modern plasma-substituting solutions and a solution of 0,9 % sodium chloride.\",\"PeriodicalId\":220616,\"journal\":{\"name\":\"Novejshie zarubezhnye i otechestvennye lekarstvennye preparaty: farmakoterapija, farmakodinamika, farmakokinetika (Newest Foreign and Domestic Preparations: Pharmacotherapy, Pharmacodynamics, Pharmacokinetics)\",\"volume\":\"203 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Novejshie zarubezhnye i otechestvennye lekarstvennye preparaty: farmakoterapija, farmakodinamika, farmakokinetika (Newest Foreign and Domestic Preparations: Pharmacotherapy, Pharmacodynamics, Pharmacokinetics)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33920/med-06-2003-01\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Novejshie zarubezhnye i otechestvennye lekarstvennye preparaty: farmakoterapija, farmakodinamika, farmakokinetika (Newest Foreign and Domestic Preparations: Pharmacotherapy, Pharmacodynamics, Pharmacokinetics)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33920/med-06-2003-01","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Controlled and uncontrolled physicochemical quality indicators of 0.9 % sodium chloride of various manufacturers
The article presents the results of studies of osmolality and pH of 0,9 % sodium chloride of various manufacturers. To obtain data on the pH value, the data used in the passports are used, and the indicators of its osmolality are de- termined using laboratory tests. 0,9 % sodium chloride from different manufacturers has different pH and osmolality. Knowing the actual values of physico-chemical parameters can increase the accuracy of the results of future clinical studies, which compare the pharmacokinetics and pharmacodynamics of modern plasma-substituting solutions and a solution of 0,9 % sodium chloride.
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