S J Proskurjakov, O A Smoryzanova, N I Rjabcenko, A N Dedenkov
{"title":"[甲硝唑和异甲硝唑(1-(2-羟乙基)-2-甲基-4-硝基咪唑)的辐射致敏活性]。","authors":"S J Proskurjakov, O A Smoryzanova, N I Rjabcenko, A N Dedenkov","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of irradiation, metronidazole and iso-metronidazole on survival and number of tumor cells was analysed in vitro in mice that were inoculated with La-hemocytoblastosis--or Ehrlich-ascites-tumor cells after processing. It was shown that metronidazole and iso-metronidazole nearly have the same radiosensitizing activity on these conditions. The effect was dependent on concentration of compounds and cell type. With intraperitoneal application the iso-metronidazole was eliminated from Lewis-lung-carcinoma more slowly than from blood.</p>","PeriodicalId":76404,"journal":{"name":"Radiobiologia, radiotherapia","volume":"31 6","pages":"531-6"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The radiation sensitizing activity of metronidazole and iso-metronidazole (1-(2-hydroxyethyl)-2-methyl-4-nitroimidazole)].\",\"authors\":\"S J Proskurjakov, O A Smoryzanova, N I Rjabcenko, A N Dedenkov\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effect of irradiation, metronidazole and iso-metronidazole on survival and number of tumor cells was analysed in vitro in mice that were inoculated with La-hemocytoblastosis--or Ehrlich-ascites-tumor cells after processing. It was shown that metronidazole and iso-metronidazole nearly have the same radiosensitizing activity on these conditions. The effect was dependent on concentration of compounds and cell type. With intraperitoneal application the iso-metronidazole was eliminated from Lewis-lung-carcinoma more slowly than from blood.</p>\",\"PeriodicalId\":76404,\"journal\":{\"name\":\"Radiobiologia, radiotherapia\",\"volume\":\"31 6\",\"pages\":\"531-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiobiologia, radiotherapia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiobiologia, radiotherapia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[The radiation sensitizing activity of metronidazole and iso-metronidazole (1-(2-hydroxyethyl)-2-methyl-4-nitroimidazole)].
The effect of irradiation, metronidazole and iso-metronidazole on survival and number of tumor cells was analysed in vitro in mice that were inoculated with La-hemocytoblastosis--or Ehrlich-ascites-tumor cells after processing. It was shown that metronidazole and iso-metronidazole nearly have the same radiosensitizing activity on these conditions. The effect was dependent on concentration of compounds and cell type. With intraperitoneal application the iso-metronidazole was eliminated from Lewis-lung-carcinoma more slowly than from blood.
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