从血清中分离的巨量糖肽的免疫调节特性。2巨噬细胞和多形核细胞的活化。

Q4 Biochemistry, Genetics and Molecular Biology

Acta Microbiologica Bulgarica Pub Date : 1990-01-01

Kh Neĭchev, N Ivanovska, L Shirova, E Slavcheva, P Stoianova, D Georgiev, I Abrashev, P Velcheva, I Ianchev

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引用次数: 0

摘要

研究了由不同碳水化合物和肽组分组成的糖宏肽的三组分的刺激特性。多形核的吞噬活性在给药后24小时增加，巨噬细胞的吞噬活性在给药后3天增加。体外部分3刺激巨噬细胞溶菌酶活性和蛋白质合成及Clq补体。细胞的这些特性是由已建立的超微结构变化协同作用的。不同组分的组成决定了它们的免疫刺激作用。

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[The immunomodulating properties of a macro glycopeptide isolated from serum. II. The activation of macrophages and polymorphonuclear cells].

The stimulating properties of three fractions of a glucomacropeptide consisting of different carbohydrate and peptide components were studied. The phagocytic activity of polymorphonuclears was increased on the 24th hour and of macrophages on the 3rd day after application of the preparations to mice. In vitro fraction 3 stimulates the lysozyme activity and the synthesis of proteins and Clq of the macrophages complement. These properties of the cells are collaborated by the established ultrastructural changes. The different composition of the fractions determines their immunostimulating effect.

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来源期刊

Acta Microbiologica Bulgarica Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

0.40

自引率

0.00%

发文量