Acantholytic variant of seborrheic keratoses: Uncommon histological feature

Seborrheic keratoses are common benign cutaneous neoplasms. Here we report a case because of the peculiar histological appearance characterized by acantholysis. An elderly woman presented with gradually progressive keratotic nodular growth over her thigh. Although the basic histologic findings suggestive of seborrheic keratosis like papillomatosis, acanthosis, hyperkeratosis, presence of horn pseudocyst and squamous eddies were present with upper layers of epidermis showed focal spongiosis and acantholysis. Differentiation with acantholytic dyskeratotic acanthoma, warty dyskeratoma, acantholytic actinic keratosis could be made on histological features. Although the histogenesis is uncertain, it seems that acantholytic variant is a rare variant of irritated seborrheic keratosis.