转化生长因子:一种肿瘤发育生长因子。

IF 3.5 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
D S Salomon, N Kim, T Saeki, F Ciardiello
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引用次数: 0

摘要

转化生长因子- α (tgf - α)是一种50个氨基酸的有丝分裂肽,在结构上,在某些情况下,与表皮生长因子(EGF)肽家族成员在功能上相关。tgf - α最初是作为一种高分子量、糖基化的膜相关前体合成的,大约有160个氨基酸。低分子量tgf - α肽及其前体在许多系统中具有生物活性,并且在过度表达时可以发挥转化蛋白质的作用。tgf - α结合并激活EGF受体,tgf - α和EGF受体在许多人类和啮齿动物的肿瘤和肿瘤细胞系中共表达,这表明tgf - α可以作为自分泌或旁分泌生长因子发挥作用。在发育过程中,tgf - α在一些胎儿和邻近的母体组织中短暂表达,也在许多成人组织中表达;这种表达模式表明生长因子参与了几种不同的生理功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transforming growth factor-alpha: an oncodevelopmental growth factor.

Transforming growth factor-alpha (TGF-alpha) is a 50-amino-acid mitogenic peptide that is structurally and, in some cases, functionally related to members of the epidermal growth factor (EGF) family of peptides. TGF-alpha is initially synthesized as a high-molecular-weight, glycosylated, membrane-associated precursor of approximately 160 amino acids. The low-molecular-weight TGF-alpha peptide as well as the precursor are biologically active in a number of systems and can function as transforming proteins when overexpressed. TGF-alpha binds to and activates the EGF receptor, and TGF-alpha and the EGF receptor are coexpressed in a number of human and rodent tumors and tumor cell lines--which suggests that TGF-alpha can function as an autocrine or paracrine growth factor. TGF-alpha is transiently expressed in some fetal and adjacent maternal tissues during development and is also expressed in a number of adult tissues; this pattern of expression suggests that the growth factor is involved in several distinct physiological functions.

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