设计具有潜在生物学应用的定制薄膜表面的概念

N. Muzzio, O. Azzaroni, S. Moya, M. Pasquale
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引用次数: 3

摘要

纳米结构薄膜的表面剪裁,其界面特性可以在纳米尺度上控制,为生物应用提供了多种可能性。设计具有适当性质的薄膜,以在细胞水平上诱导所需的生物反应,需要物理学、化学、材料科学、生物学和医学的研究融合。在这里,我们将讨论决定分离细胞、细胞菌落和组织与材料相互作用行为的主要表面特性。表面粗糙度、形态特征、刚度、润湿性、化学性质、蛋白质-表面相互作用特征以及时空-孔隙异质性,将有助于材料的理想生物性能。本文将简要介绍薄膜在生物领域的应用。我们将重点介绍一些例子,其中基本而简单的过程在确定触发特定生物细胞表型方面起关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Concepts for Designing Tailored Thin Film Surfaces with Potential Biological Applications
The tailoring of surfaces with nanostructured thin films, where interfacial properties can be controlled at the nanoscale, offers multiple possibilities for biological applications. The design of thin films with appropriate properties to induce desired biological responses at cell level requires the convergence of research from physics, chemistry, material science, biology, and medicine. Here, we will discuss the main surface properties that determine the behavior of isolated cells, cell colonies, and tissues interacting with a material. Surface roughness, morphological features, stiffness, wettability, chemical nature, and protein-surface interaction characteristics, as well as spatiotem-poral heterogeneities, are expected to contribute to the desired biological performance of a material. A brief review in relation to thin films for biological applications will be presented. We will focus on examples in which basic rather simple processes play a key role in determining the triggering of a particular biological cell phenotype.
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