Comparative Evaluation of the Effects of Low-Level Laser Therapy and Ozone Application on Wound Healing After Gingivectomy and Gingivoplasty: A Randomized Control Clinical Trial

AIM: The aim of this randomized controlled clinical trial was to clinically evaluate and compare the effect of ozonated water and Low level laser therapy (LLLT) on the early wound healing period of gingivectomy and gingivoplasty wounds by clinical analysis. Materials & Methods: Forty-five patients were randomly allocated into 3 groups, test group 1 (ozone therapy n=15), test group 2 (LLLT application n=14) and control group (no treatment n=15). Ozone irrigation was done on the surgical site with a concentration of 4ppm for 5-10 minutes, LLLT application was performed with diode LASER (810 nm) immediately after the surgical therapy and on day 3, day 7, day 21. Wound surface area, wound healing index, quality of life, plaque index, sulcus bleeding index were investigated. Results: At day 21 statistically significant smaller wounds were observed in both ozone and LLLT groups compared to control group. However, intergroup comparison between the ozone and LLLT group did not show statistically significant difference in wound surface area evaluated by staining technique and image J analysis. The wound healing index, VAS score OHIP -14 questionnaire, analgesics consumed, plaque index, sulcus bleeding index showed a statistically significant reduction from baseline to day 21in all groups. Conclusion: Ozone therapy is safe and effective in promoting wound healing during the 1st 3 weeks post-surgery. Ozone therapy and LLLT application enhanced wound healing after gingivectomy and gingivoplasty procedures, accompanied by better quality of life and reduced pain .