Factors Affecting the Proliferation Ability of Cardiomyocytes

Heart disease is a highly lethal disease that causes a large number of deaths worldwide every year. When heart disease happened, it will cause the death of a large number of cardiomyocytes. Because of the proliferation capacity of mammalian cardiomyocytes is limited, it's unable for cardiomyocytes to compensate the damage through their own proliferation, resulting in severe damage to the heart function, and ultimately leading to death. Therefore, how to improve the proliferation of cardiomyocytes during the occurrence of heart disease has become a key issue in the study of heart disease. In this review, we discuss the factors that affect the proliferative ability of cardiomyocytes, namely, oxygen concentration, and transcription factors, so as to contribute to the treatment of heart diseases.