{"title":"双侧卵巢切除大鼠心脏及主动脉形态学变化分析雌二醇对心脏和血管的保护作用","authors":"A. N. Karachentsev, I. A. Melchenko","doi":"10.14341/probl199844235-39","DOIUrl":null,"url":null,"abstract":"The effect of bilateral oophorectomy on the structure of the heart and aorta and changes in their structure during substitution estradiol therapy were assessed in rats. Estrogen deficit led to development of nonspecific changes in myocardial and aortic microstructure with tissue edema. Substitute estradiol therapy protected the oophorectomized animals from stress-dependent morphological changes of the cardiovascular system.","PeriodicalId":342539,"journal":{"name":"Problems of Endocrinology","volume":"2 3","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Morphological analysis of changes in the heart and aorta of rats undergoing bilateral ovariectomy; cardio- and vasoprotective effects of estradiol\",\"authors\":\"A. N. Karachentsev, I. A. Melchenko\",\"doi\":\"10.14341/probl199844235-39\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The effect of bilateral oophorectomy on the structure of the heart and aorta and changes in their structure during substitution estradiol therapy were assessed in rats. Estrogen deficit led to development of nonspecific changes in myocardial and aortic microstructure with tissue edema. Substitute estradiol therapy protected the oophorectomized animals from stress-dependent morphological changes of the cardiovascular system.\",\"PeriodicalId\":342539,\"journal\":{\"name\":\"Problems of Endocrinology\",\"volume\":\"2 3\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Problems of Endocrinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14341/probl199844235-39\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Problems of Endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14341/probl199844235-39","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Morphological analysis of changes in the heart and aorta of rats undergoing bilateral ovariectomy; cardio- and vasoprotective effects of estradiol
The effect of bilateral oophorectomy on the structure of the heart and aorta and changes in their structure during substitution estradiol therapy were assessed in rats. Estrogen deficit led to development of nonspecific changes in myocardial and aortic microstructure with tissue edema. Substitute estradiol therapy protected the oophorectomized animals from stress-dependent morphological changes of the cardiovascular system.
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