M. K. Hole, S. Rider, Paul Kwon, R. Worth, Liang Cheng, E. Hattab, Tina Y. Fodrie, V. Salanova, D. Sokol
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Search for Human Herpesvirus-6 in Mesial Temporal Lobe Epilepsy Surgical Brain Resections
Human Herpesvirus-6 (HHV-6) causes roseola infantum and has been associated with multiple sclerosis, seizures, meningitis, and meningoencephalitis. A 2003 study isolated HHV-6 DNA in astrocyte-resembling cells of temporal lobe surgical brain tissue resections in four of eight patients with mesial temporal lobe epilepsy (MTLE). This suggests that the initial infection or reactivation of HHV-6 in astrocytes plays a role in the development of MTLE. We sought to replicate this finding in 18 patients undergoing lobectomy for medically refractory seizures with history of roseola and MTLE. We found no evidence of HHV-6 DNA in temporal lobe specimens of 18 patients with MTLE.
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