{"title":"大鼠基因组数据库中的通路资源:一个整合基因、通路和疾病信息的动态平台","authors":"V. Petri","doi":"10.4018/978-1-60960-491-2.ch014","DOIUrl":null,"url":null,"abstract":"The set of interacting molecules representing a biological pathway or network is a central concept in biology. It is within the pathway context that the functioning of individual molecules acquires purpose and it is the integration of these molecular circuitries that underlies the functioning of biological systems. In order to provide the research community with a dynamic platform for accessing pathway information, the Rat Genome Database (RGD – http://rgd.mcw.edu) is using a multi-tiered approach. In this chapter, the pathway resources that RGD currently offers are presented. Issues covered include: the biological pathway, the concept and the ontology, pathway literature curation and annotation of genes, interactive pathway diagrams, and tools and resources to access and navigate between pathway data. A case study is presented; future directions are discussed. DOI: 10.4018/978-1-60960-491-2.ch014","PeriodicalId":254251,"journal":{"name":"Handbook of Research on Computational and Systems Biology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Pathway Resources at the Rat Genome Database: A Dynamic Platform for Integrating Gene, Pathway and Disease Information\",\"authors\":\"V. Petri\",\"doi\":\"10.4018/978-1-60960-491-2.ch014\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The set of interacting molecules representing a biological pathway or network is a central concept in biology. It is within the pathway context that the functioning of individual molecules acquires purpose and it is the integration of these molecular circuitries that underlies the functioning of biological systems. In order to provide the research community with a dynamic platform for accessing pathway information, the Rat Genome Database (RGD – http://rgd.mcw.edu) is using a multi-tiered approach. In this chapter, the pathway resources that RGD currently offers are presented. Issues covered include: the biological pathway, the concept and the ontology, pathway literature curation and annotation of genes, interactive pathway diagrams, and tools and resources to access and navigate between pathway data. A case study is presented; future directions are discussed. DOI: 10.4018/978-1-60960-491-2.ch014\",\"PeriodicalId\":254251,\"journal\":{\"name\":\"Handbook of Research on Computational and Systems Biology\",\"volume\":\"29 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Handbook of Research on Computational and Systems Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4018/978-1-60960-491-2.ch014\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Handbook of Research on Computational and Systems Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4018/978-1-60960-491-2.ch014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pathway Resources at the Rat Genome Database: A Dynamic Platform for Integrating Gene, Pathway and Disease Information
The set of interacting molecules representing a biological pathway or network is a central concept in biology. It is within the pathway context that the functioning of individual molecules acquires purpose and it is the integration of these molecular circuitries that underlies the functioning of biological systems. In order to provide the research community with a dynamic platform for accessing pathway information, the Rat Genome Database (RGD – http://rgd.mcw.edu) is using a multi-tiered approach. In this chapter, the pathway resources that RGD currently offers are presented. Issues covered include: the biological pathway, the concept and the ontology, pathway literature curation and annotation of genes, interactive pathway diagrams, and tools and resources to access and navigate between pathway data. A case study is presented; future directions are discussed. DOI: 10.4018/978-1-60960-491-2.ch014
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