CD30-positive T-cell lymphoproliferation of the bulbar conjuntival mucosa showing spontaneous remission

Introduction: CD30-positive T-cell lymphoproliferative lesions represent a spectrum of heterogeneous disorders. Clinical case: An incision biopsy was performed in a 25-year-old man with a lump in the bulbar conjunctiva. Immunohistochemistry indicated membrane positivity for CD3 and CD30 in over 75%. PCR identified the monoclonal nature of the T-cells. The hematological study was normal. Following biopsy, the conjunctival tumor diminished until disappear. Conclusions: Mucosal CD30-positive T-cell lymphoproliferation could be ascribed to a reactive process but it is necessary to rule out a primary conjunctival tumor or the first manifestation of an anaplastic large cell lymphoma.