川武治疗类风湿关节炎的途径富集分析

Hongtao Guo, Lingru Wang, Rong Li, Ting Hao, Guang Zheng
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引用次数: 0

摘要

由于研究有限,目前尚缺乏川乌抗类风湿关节炎的通路网络,为进一步研究提供线索。本研究从化学成分入手,对川武靶向蛋白进行了探索。之后,我们对富集了这些靶向蛋白的通路网络进行了分析,在p值阈值为0.001的情况下进行了超几何分布的药理机制分析。同时,以同样的方法计算富含OMIM基因的类风湿关节炎通路网络进行病理分析。然后,这两个通路网络的药理学和病理学合并为一个验证和进一步的预测。结果,预测了六个通路网络,它们可能对类风湿关节炎的治疗作用负责。它们是:疾病、信号转导、蛋白质代谢、细胞周期、蛋白质代谢和发育生物学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathway enrichment analysis of Chuan-wu for rheumatoid arthritis
With limited researches, there is still lack of pathway networks of Chuan-wu (also called Aconitum carmichaelii) against rheumatoid arthritis which might provide clues for further researches. In this study, started from the chemical compounds, proteins targeted by Chuan-wu were explored. After that, pathway networks enriched with these targeted proteins were analyzed with hypergeometric distribution on threshold ofp-value set to 0.001 for pharmacology mechanism. Meanwhile, pathway networks enriched with OMIM genes of rheumatoid arthritis were also calculated for pathology analysis in the same way. Then, these two pathway networks of pharmacology and pathology were merged into one for validation and further predictions. As a result, six pathway networks were predicted which might be responsible for the therapeutic effect against rheumatoid arthritis. They are: disease, signal transduction, metabolism of proteins, cell cycle, metabolism of proteins, and developmental biology.
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