Miftakhul Rosidah, Heni Widayani, Usman Pagalay
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引用次数: 0

摘要

由人乳头瘤病毒(HPV)引起的宫颈癌在印度尼西亚是一个严重的健康问题。尽管已经发现了一种疫苗,并在印度尼西亚的卫生设施中进行了筛查,但HPV的传播仍然是一个未解决的问题。本研究通过将人群分为易感人群(S(t))、接种人群(V(t))、未察觉感染人群(I〗_u (t))、感染人群和筛查人群(I〗_s (t))、宫颈癌暴露人群(C(t))和治愈人群(R(t)) 6个亚人群,对HPV传播模型进行了动态分析。该模型描述了HPV的动态传播速率,它有两个平衡点,即无病平衡点和地方性平衡点。本研究结果表明,无病平衡点是不稳定的,这意味着种群中仍有可能发生感染。数值模拟表明,接种疫苗的个人百分比将减少无意识感染者和宫颈癌患者人数的增加。提高人群的筛查率也将减少无意识感染和宫颈癌患者的人数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ANALISIS DINAMIK PENYEBARAN HUMAN PAPILLOMAVIRUS DENGAN PENGARUH VAKSINASI DAN SKRINING
Cervical cancer caused by Human Papillomavirus (HPV) is a serious health problem in Indonesia. The spread of HPV is still an unresolved problem even though a vaccine has been found and screening has been carried out in health facilities in Indonesia. In this study, the dynamic analysis of the HPV spread model was studied by categorizing the population into 6 sub-populations, namely the susceptible individual population (S(t)),  the vaccinated individual population (V(t)), the infected individual population who were not aware 〖(I〗_u (t)), population of infected and screened individuals 〖(I〗_s (t)), population of individuals exposed to cervical cancer (C(t)), and population of cured individuals (R(t)). The model describes the dynamic rate of HPV spread which has two equilibrium points, namely the disease-free equilibrium point and the endemic equilibrium point. The results of this study indicate that the disease-free equilibrium point is unstable, meaning that there is still a possibility that infection will occur in the population. The numerical simulation illustrates that the percentage of individuals who are vaccinated will reduce the increase in the number of unconscious infected individuals and individuals with cervical cancer. Increasing the screening rate in the population will also reduce the number of unconsciously infected individuals and individuals with cervical cancer.
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