D. Adeyemi, O. Komolafe, S. O. Adewole, E. Obuotor, T. Adenowo
{"title":"野牡丹对实验性糖尿病大鼠胰岛细胞形态的影响","authors":"D. Adeyemi, O. Komolafe, S. O. Adewole, E. Obuotor, T. Adenowo","doi":"10.5580/229c","DOIUrl":null,"url":null,"abstract":"The study was designed to evaluate the effects of methanolic extract of Annona muricata leaves on the pancreatic islet cells of streptozotocin induceddiabetic rats. Thirty adult Wistar rats were randomly assigned into three groups (A, B and C) of ten rats each. Group A was the control, Group B was untreated diabetic group and group C was A. muricata-treated group. Diabetes mellitus was experimentally induced in groups B and C by a single intra-peritoneal injection of 80mg/kg streptozotocin dissolved in 0.1M citrate buffer. Group A rats were intraperitoneally injected with equivalent volume of citrate buffer. Daily intra peritoneal injection of 100mg/kg A. muricata was administered to group C rats for two weeks. The rats were sacrificed and the pancreas were removed and fixed in Bouins fluid. The tissues were processed for paraffin embedding and sections of 5μm thickness were produced and stained. Histopathological examination of the stained sections showed regeneration β-cells of islets of pancreas of A. muricata-treated rats when compared to untreated diabetic group of rats.","PeriodicalId":107168,"journal":{"name":"The Internet Journal of Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"16","resultStr":"{\"title\":\"Effects Of Annona Muricata (Linn) On The Morphology Of Pancreatic Islet Cells Of Experimentally-Induced Diabetic Wistar Rats\",\"authors\":\"D. Adeyemi, O. Komolafe, S. O. Adewole, E. Obuotor, T. Adenowo\",\"doi\":\"10.5580/229c\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The study was designed to evaluate the effects of methanolic extract of Annona muricata leaves on the pancreatic islet cells of streptozotocin induceddiabetic rats. Thirty adult Wistar rats were randomly assigned into three groups (A, B and C) of ten rats each. Group A was the control, Group B was untreated diabetic group and group C was A. muricata-treated group. Diabetes mellitus was experimentally induced in groups B and C by a single intra-peritoneal injection of 80mg/kg streptozotocin dissolved in 0.1M citrate buffer. Group A rats were intraperitoneally injected with equivalent volume of citrate buffer. Daily intra peritoneal injection of 100mg/kg A. muricata was administered to group C rats for two weeks. The rats were sacrificed and the pancreas were removed and fixed in Bouins fluid. The tissues were processed for paraffin embedding and sections of 5μm thickness were produced and stained. Histopathological examination of the stained sections showed regeneration β-cells of islets of pancreas of A. muricata-treated rats when compared to untreated diabetic group of rats.\",\"PeriodicalId\":107168,\"journal\":{\"name\":\"The Internet Journal of Alternative Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet Journal of Alternative Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5580/229c\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet Journal of Alternative Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/229c","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects Of Annona Muricata (Linn) On The Morphology Of Pancreatic Islet Cells Of Experimentally-Induced Diabetic Wistar Rats
The study was designed to evaluate the effects of methanolic extract of Annona muricata leaves on the pancreatic islet cells of streptozotocin induceddiabetic rats. Thirty adult Wistar rats were randomly assigned into three groups (A, B and C) of ten rats each. Group A was the control, Group B was untreated diabetic group and group C was A. muricata-treated group. Diabetes mellitus was experimentally induced in groups B and C by a single intra-peritoneal injection of 80mg/kg streptozotocin dissolved in 0.1M citrate buffer. Group A rats were intraperitoneally injected with equivalent volume of citrate buffer. Daily intra peritoneal injection of 100mg/kg A. muricata was administered to group C rats for two weeks. The rats were sacrificed and the pancreas were removed and fixed in Bouins fluid. The tissues were processed for paraffin embedding and sections of 5μm thickness were produced and stained. Histopathological examination of the stained sections showed regeneration β-cells of islets of pancreas of A. muricata-treated rats when compared to untreated diabetic group of rats.
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