Indicators of endogenous intoxication in assessing the effectiveness of hepatosis therapy in cattle

The article presents the results of assessing the indicators of endogenous intoxication in the process of pharmacotherapy of hepatosis in cattle. Dairy cows (n=20) diagnosed with hepatosis were treated with flavobetin, which was used daily for a month at a dose of 50 g/animal per day. In the dynamics of therapy in cows, laboratory blood tests were carried out, on the basis of which it was found that during hepatosis disturbances in protein, carbohydrate and lipid metabolism were registered and the activity of hepatoindicator enzymes also increased. With liver dystrophy in the blood of cattle a higher level of markers of endogenous intoxication represented by medium mass molecules (MMM) of the relatively healthy livestock was revealed. Course treatment with flavobetin has a pronounced positive clinical and laboratory effect in hepatobiliary disorders in cattle. In the process of recovery there was a decrease in the level of endogenous intoxication in the body of cows, which was confirmed by a lower level of MMM in the blood. Determination of these markers of endotoxicosis may have prognostic value in monitoring the dynamics of the state of the liver and evaluating the effectiveness of drug therapy for hepatopathologies in cattle.