口腔内的外阴显微微生物的表现和发育

I. Gunawan, R. Setiadhi
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摘要

背景:寻常型天疱疮(Pemphigus Vulgaris, PV)是一种累及皮肤和粘膜的自身免疫性上皮内起泡性疾病。口腔病变可能是该疾病的第一个迹象,其次是皮肤和其他粘膜部位的累及。目的:报告寻常型天疱疮口腔表现的病例,旨在帮助临床医生认识和治疗口腔病变。病例报告:男性27岁,因皮肤及口腔黏膜多发水疱入住RSUP Dr.Hasan Sadikin医院,诊断为寻常型天疱疮。病例管理:患者使用类固醇漱口水和口腔膏治疗。经过两个月的治疗,患者口腔病变完全恢复。讨论:在PV中,针对桥粒特异性地产生自身抗体,特别是桥粒蛋白3,它负责将上皮细胞固定在一起。由于抗dsg3抗体导致粘附功能丧失,导致口腔黏膜形成大疱。PV的病因尚不清楚。结论:早期识别和治疗口腔病变是预防皮肤受累的重要措施。早期治疗、患者的依从性和多学科合作是本病治疗成功的保证
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MANIFESTASI DAN PENATALAKSANAAN PEMFIGUS VULGARIS DI RONGGA MULUT
Background : Pemphigus Vulgaris (PV) is an autoimmune intraepithelial blistering disease involving the skin and mucous membranes. Oral lesions could be the first sign of the disease followed by the involvement of skin and other mucosa sites.Objectives : This is oral manifestations of pemphigus vulgaris case report, intended to help clinicians to recognize and treat the oral lesions.Case Reported : Male 27 yo admitted to RSUP Dr.Hasan Sadikin hospital with multiple blisters on the skin and oral mucosa, was diagnosed with Pemphigus Vulgaris.Case Management : Patient was treated with steroid mouth wash and oral paste. After two months of treatment, the patient was fully recovered from oral lesion.Discussion : In PV, autoantibodies are produced against desmosomes spesifically desmoglein 3 which responsible for holding the cells of the epithelium together. The loss of adhesive function due to anti Dsg 3 antibodies result in bulla formation on the oral mucosa.The aetiology for PV is still uncertain. Conclusion :Early recognition and treatment of oral lesions is important as it may prevent skin involvement. Early treatment, patient’s compliance and multi disciplinal teamwork ensure the treatment succes for this disease
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