SARS-CoV-2 ORF10通过增强CUL2ZYG11B活性损害纤毛

The Journal of Cell Biology Pub Date : 2022-06-08 DOI:10.1083/jcb.202108015

Liying Wang, Chao Liu, Bo Yang, Haotian Zhang, J. Jiao, Ruidan Zhang, Shujun Liu, Sai Xiao, Yinghong Chen, Bo Liu, Yanjie Ma, Xuefeng Duan, Yueshuai Guo, Mengmeng Guo, Bingbing Wu, Xiangdong Wang, Xingxu Huang, Haitao Yang, Yaoting Gui, Min Fang, Luo Zhang, Shuguang Duo, Xuejiang Guo, Wei Li

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引用次数: 15

摘要

Wang等人报道，SARS-CoV-2 ORF10通过刺激CUL2ZYG11B活性促进IFT46降解，从而损害纤毛的生物发生和维持。该研究提供了将COVID-19症状与纤毛功能障碍联系起来的病理机制。

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SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity

Wang et al. report that the SARS-CoV-2 ORF10 promotes IFT46 degradation via stimulating CUL2ZYG11B activity, thereby impairing both cilia biogenesis and maintenance. The study provides a pathological mechanism connecting COVID-19 symptoms with cilia dysfunction.

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The Journal of Cell Biology

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