用于耐甲氧西林金黄色葡萄球菌治疗的亚麻酸纳米脂质体

2022 14th Biomedical Engineering International Conference (BMEiCON) Pub Date : 2022-11-10 DOI:10.1109/BMEiCON56653.2022.10012101

Azmee Okriss, Julinthip Puttawong, Mingkwan Yingkajorn, Somyot Chirasatitsin, Soracha D. Thamphiwatana

{"title":"用于耐甲氧西林金黄色葡萄球菌治疗的亚麻酸纳米脂质体","authors":"Azmee Okriss, Julinthip Puttawong, Mingkwan Yingkajorn, Somyot Chirasatitsin, Soracha D. Thamphiwatana","doi":"10.1109/BMEiCON56653.2022.10012101","DOIUrl":null,"url":null,"abstract":"Methicillin-resistant Staphylococcus aureus (MRSA) presents a major threat to a broad range of healthcare and community associated infections. MRSA bacteria have rapidly developed resistance to multiple drugs throughout the antibiotic history. It is imperative to develop novel antimicrobial strategies to address the currently shrinking therapeutic options against MRSA. Herein, we developed a nanoliposome formulation of natural antimicrobial compound such as linolenic acid and evaluate its potential application for the treatment of MRSA infection as well as its safety. We found that Nano-liposomal linolenic acid (LipoLNA) was successfully synthesized. LipoLNA was able to inhibit MRSA growth and exhibited a good safety profile on normal mammalian cells.","PeriodicalId":177401,"journal":{"name":"2022 14th Biomedical Engineering International Conference (BMEiCON)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nanoliposome of Linolenic acid for Methicillin-resistant Staphylococcus aureus treatment\",\"authors\":\"Azmee Okriss, Julinthip Puttawong, Mingkwan Yingkajorn, Somyot Chirasatitsin, Soracha D. Thamphiwatana\",\"doi\":\"10.1109/BMEiCON56653.2022.10012101\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Methicillin-resistant Staphylococcus aureus (MRSA) presents a major threat to a broad range of healthcare and community associated infections. MRSA bacteria have rapidly developed resistance to multiple drugs throughout the antibiotic history. It is imperative to develop novel antimicrobial strategies to address the currently shrinking therapeutic options against MRSA. Herein, we developed a nanoliposome formulation of natural antimicrobial compound such as linolenic acid and evaluate its potential application for the treatment of MRSA infection as well as its safety. We found that Nano-liposomal linolenic acid (LipoLNA) was successfully synthesized. LipoLNA was able to inhibit MRSA growth and exhibited a good safety profile on normal mammalian cells.\",\"PeriodicalId\":177401,\"journal\":{\"name\":\"2022 14th Biomedical Engineering International Conference (BMEiCON)\",\"volume\":\"3 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-11-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2022 14th Biomedical Engineering International Conference (BMEiCON)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/BMEiCON56653.2022.10012101\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2022 14th Biomedical Engineering International Conference (BMEiCON)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/BMEiCON56653.2022.10012101","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

耐甲氧西林金黄色葡萄球菌(MRSA)对广泛的医疗保健和社区相关感染构成重大威胁。在整个抗生素历史中，MRSA细菌迅速对多种药物产生耐药性。必须开发新的抗微生物策略，以解决目前针对MRSA的治疗方案不断缩小的问题。在此，我们开发了一种天然抗菌化合物如亚麻酸的纳米脂质体配方，并评估其在治疗MRSA感染方面的潜在应用及其安全性。我们成功合成了纳米亚麻酸脂质体(LipoLNA)。LipoLNA能够抑制MRSA的生长，并在正常哺乳动物细胞中表现出良好的安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Nanoliposome of Linolenic acid for Methicillin-resistant Staphylococcus aureus treatment

Methicillin-resistant Staphylococcus aureus (MRSA) presents a major threat to a broad range of healthcare and community associated infections. MRSA bacteria have rapidly developed resistance to multiple drugs throughout the antibiotic history. It is imperative to develop novel antimicrobial strategies to address the currently shrinking therapeutic options against MRSA. Herein, we developed a nanoliposome formulation of natural antimicrobial compound such as linolenic acid and evaluate its potential application for the treatment of MRSA infection as well as its safety. We found that Nano-liposomal linolenic acid (LipoLNA) was successfully synthesized. LipoLNA was able to inhibit MRSA growth and exhibited a good safety profile on normal mammalian cells.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

2022 14th Biomedical Engineering International Conference (BMEiCON)

自引率

0.00%

发文量