{"title":"[钙通道阻滞剂对6-羟多巴胺损伤大鼠阿波啡和安非他明所致旋转的影响]。","authors":"C Tabernero, B Pardo, J García de Yébenes","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We have studied the effects of calcium channel blockers cinarizine, flunarizine, nicardipine, nifedipine, verapamil and diltiazem on the motor anomalies which can be found in rats with unilateral nigrostriated lesion due to 6-OH-DA. All of them reduce rotation induced by apomorphine according to this order: nifedipine greater than nicardipine greater than diltiazem greater than flunarizine greater than verapamil greater than cinarizine. No effects on rotation induced by amphetamine have been observed. Our data suggest that calcium channel blockers cause dopamine receptor blockade but they do not modify the calcium-non-depending releasing of dopamine induced by amphetamine.</p>","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":"54 2","pages":"49-53"},"PeriodicalIF":0.0000,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Effect of the calcium channel blockers on rotation induced by apomorphine and amphetamine in rats lesioned with 6-hydroxydopamine].\",\"authors\":\"C Tabernero, B Pardo, J García de Yébenes\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We have studied the effects of calcium channel blockers cinarizine, flunarizine, nicardipine, nifedipine, verapamil and diltiazem on the motor anomalies which can be found in rats with unilateral nigrostriated lesion due to 6-OH-DA. All of them reduce rotation induced by apomorphine according to this order: nifedipine greater than nicardipine greater than diltiazem greater than flunarizine greater than verapamil greater than cinarizine. No effects on rotation induced by amphetamine have been observed. Our data suggest that calcium channel blockers cause dopamine receptor blockade but they do not modify the calcium-non-depending releasing of dopamine induced by amphetamine.</p>\",\"PeriodicalId\":8654,\"journal\":{\"name\":\"Archivos de neurobiologia\",\"volume\":\"54 2\",\"pages\":\"49-53\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archivos de neurobiologia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivos de neurobiologia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Effect of the calcium channel blockers on rotation induced by apomorphine and amphetamine in rats lesioned with 6-hydroxydopamine].
We have studied the effects of calcium channel blockers cinarizine, flunarizine, nicardipine, nifedipine, verapamil and diltiazem on the motor anomalies which can be found in rats with unilateral nigrostriated lesion due to 6-OH-DA. All of them reduce rotation induced by apomorphine according to this order: nifedipine greater than nicardipine greater than diltiazem greater than flunarizine greater than verapamil greater than cinarizine. No effects on rotation induced by amphetamine have been observed. Our data suggest that calcium channel blockers cause dopamine receptor blockade but they do not modify the calcium-non-depending releasing of dopamine induced by amphetamine.
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