Y. Haryu, Yoko Taguchi, E. Itakura, O. Mikami, Katsuhiro Miura, Takakiyo Saeki, Y. Nakajima
{"title":"一种转基因植物的长期生物安全性评价:转基因抗虫玉米Bt11不影响小鼠多代生产性能和寿命","authors":"Y. Haryu, Yoko Taguchi, E. Itakura, O. Mikami, Katsuhiro Miura, Takakiyo Saeki, Y. Nakajima","doi":"10.2174/1874294700903010049","DOIUrl":null,"url":null,"abstract":"The longterm performance of multi-generations or life span was assessed using genetically modified (GM) insect-resistant Bt11 corn. Diet containing 68% of GM Bt11 or non-Bt isoline with sufficient nutrient composition was fed to male and female ICR mice through 5 generations. The results of growth, mating, gestation, milking periods, reproduction and life span were not different between the GM Bt11 and non-Bt fed groups. The percentage of embryonic death, litter size, newborn sex ratio and body weight (21-60 days after birth) were not different between these groups. The life span of the third-generation mice did not differ over 1,072 days of observation. In addition, there was a tendency for a weight decrease among each group as the generations progressed, but there was no significant difference in performance among each group in each generation of mice.","PeriodicalId":355995,"journal":{"name":"The Open Plant Science Journal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2009-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"17","resultStr":"{\"title\":\"Longterm Biosafety Assessment of A Genetically Modified (GM) Plant: The Genetically Modified (GM) Insect-Resistant Bt11 Corn Does Not Affect the Performance of Multi-Generations or Life Span of Mice\",\"authors\":\"Y. Haryu, Yoko Taguchi, E. Itakura, O. Mikami, Katsuhiro Miura, Takakiyo Saeki, Y. Nakajima\",\"doi\":\"10.2174/1874294700903010049\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The longterm performance of multi-generations or life span was assessed using genetically modified (GM) insect-resistant Bt11 corn. Diet containing 68% of GM Bt11 or non-Bt isoline with sufficient nutrient composition was fed to male and female ICR mice through 5 generations. The results of growth, mating, gestation, milking periods, reproduction and life span were not different between the GM Bt11 and non-Bt fed groups. The percentage of embryonic death, litter size, newborn sex ratio and body weight (21-60 days after birth) were not different between these groups. The life span of the third-generation mice did not differ over 1,072 days of observation. In addition, there was a tendency for a weight decrease among each group as the generations progressed, but there was no significant difference in performance among each group in each generation of mice.\",\"PeriodicalId\":355995,\"journal\":{\"name\":\"The Open Plant Science Journal\",\"volume\":\"17 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-09-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Plant Science Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874294700903010049\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Plant Science Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874294700903010049","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Longterm Biosafety Assessment of A Genetically Modified (GM) Plant: The Genetically Modified (GM) Insect-Resistant Bt11 Corn Does Not Affect the Performance of Multi-Generations or Life Span of Mice
The longterm performance of multi-generations or life span was assessed using genetically modified (GM) insect-resistant Bt11 corn. Diet containing 68% of GM Bt11 or non-Bt isoline with sufficient nutrient composition was fed to male and female ICR mice through 5 generations. The results of growth, mating, gestation, milking periods, reproduction and life span were not different between the GM Bt11 and non-Bt fed groups. The percentage of embryonic death, litter size, newborn sex ratio and body weight (21-60 days after birth) were not different between these groups. The life span of the third-generation mice did not differ over 1,072 days of observation. In addition, there was a tendency for a weight decrease among each group as the generations progressed, but there was no significant difference in performance among each group in each generation of mice.
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