基于观测器的内膜增生数学模型反馈控制

Jiacheng Wu, K. Cassel
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引用次数: 1

摘要

提出了一种治疗血液透析引起的内膜增生的潜在理论模型。该模型由两部分组成。第一部分是将内膜增生的发展建模为肌肉细胞从介质到管腔的扩散过程,其控制方程为偏微分方程。第二部分是设计一个基于观测器的反馈控制器来稳定系统的平衡点,对应于不发生内膜增生。模拟结果表明,在近30天的治疗中,内膜增生可减少90%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Observer-Based Feedback Control of a Mathematical Model of Intimal Hyperplasia
A theoretical model of a potential treatment for intimal hyperplasia due to hemodialysis is proposed. This model consists of two parts. The first part is modeling the development of intimal hyperplasia as a diffusion process of muscle cells from the media to the lumen, for which the governing equation is a partial differential equation. The second part is designing an observer-based feedback controller to stabilize the equilibrium point of the system, corresponding to no intimal hyperplasia. Simulation results show that the intimal hyperplasia can be reduced by 90% in nearly 30 days of treatment.
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