{"title":"基于观测器的内膜增生数学模型反馈控制","authors":"Jiacheng Wu, K. Cassel","doi":"10.1137/1.9781611973273.25","DOIUrl":null,"url":null,"abstract":"A theoretical model of a potential treatment for intimal hyperplasia due to hemodialysis is proposed. This model consists of two parts. The first part is modeling the development of intimal hyperplasia as a diffusion process of muscle cells from the media to the lumen, for which the governing equation is a partial differential equation. The second part is designing an observer-based feedback controller to stabilize the equilibrium point of the system, corresponding to no intimal hyperplasia. Simulation results show that the intimal hyperplasia can be reduced by 90% in nearly 30 days of treatment.","PeriodicalId":193106,"journal":{"name":"SIAM Conf. on Control and its Applications","volume":"5 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Observer-Based Feedback Control of a Mathematical Model of Intimal Hyperplasia\",\"authors\":\"Jiacheng Wu, K. Cassel\",\"doi\":\"10.1137/1.9781611973273.25\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A theoretical model of a potential treatment for intimal hyperplasia due to hemodialysis is proposed. This model consists of two parts. The first part is modeling the development of intimal hyperplasia as a diffusion process of muscle cells from the media to the lumen, for which the governing equation is a partial differential equation. The second part is designing an observer-based feedback controller to stabilize the equilibrium point of the system, corresponding to no intimal hyperplasia. Simulation results show that the intimal hyperplasia can be reduced by 90% in nearly 30 days of treatment.\",\"PeriodicalId\":193106,\"journal\":{\"name\":\"SIAM Conf. on Control and its Applications\",\"volume\":\"5 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"SIAM Conf. on Control and its Applications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1137/1.9781611973273.25\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"SIAM Conf. on Control and its Applications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1137/1.9781611973273.25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Observer-Based Feedback Control of a Mathematical Model of Intimal Hyperplasia
A theoretical model of a potential treatment for intimal hyperplasia due to hemodialysis is proposed. This model consists of two parts. The first part is modeling the development of intimal hyperplasia as a diffusion process of muscle cells from the media to the lumen, for which the governing equation is a partial differential equation. The second part is designing an observer-based feedback controller to stabilize the equilibrium point of the system, corresponding to no intimal hyperplasia. Simulation results show that the intimal hyperplasia can be reduced by 90% in nearly 30 days of treatment.