High performance multifunctional low-cost biosensors

The challenge for biosensors is to achieve high performance and multiple functionalities at low cost, which includes the source and readout instrumentation. Here, we describe a sensor modality utilizing guided mode resonances that can detect multiple markers for infection, that combines the sensor chip and spectrometer in a single chip and that can achieve a limit of detection as low as 1pg/ml. This performance is equivalent or better than laboratory-based techniques yet the sensor and instrumentation can be made entirely from low-cost components.