IPET-CT在肾脏和膀胱炎性疾病中的诊断效果

V. B. Berdichevsky, B. A. Berdichevsky, A. V. Romanova, F. R. Rasulov, A. A. Naletov, S. V. Khilkevich, E. .. Gutrova, A. L. Boldyrev, M. A. Korabelnikov
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摘要

介绍。将正电子发射断层扫描和计算机断层扫描(PET-CT)结合到临床实践中,极大地扩展了对许多疾病发病机制的理解。关于感染性和炎症性疾病诊断效果的循证数据越来越多,使得这种成像方法非常有前景。研究目的:目的探讨18F-FDG PET-CT对肾脏、膀胱各种慢性炎症性疾病的诊断价值。材料和方法。回顾性分析45例患者全身18F-FDG PET-CT检查结果。患者在未涉及泌尿生殖系统的T1N0M0期肛门生殖区局部肿瘤手术治疗后的不同时间接受调查。24例有慢性肾盂肾炎病史,21例有放射性膀胱炎表现。在炎性泌尿系统疾病治疗一个疗程后,反复进行PET/CT扫描,以评估基础病理的治疗效果。慢性肾衰竭的潜伏过程伴随着肾实质中18F-FDG代谢的弥漫性降低,并在致病因治疗和尿卫生后部分恢复。放射性膀胱炎表现期间,膀胱壁检测到18F-FDG的高代谢,在治疗和泌尿综合征症状缓解期间,该代谢水平趋于平稳。细菌性炎症和放射性炎症对病原体的分子细胞反应不同,而尿液分析结果表明治疗的有效性,与所研究组织恢复足够能量代谢的视觉和数字指标相吻合。肾脏和膀胱中18F-FDG的代谢可以客观地反映炎症的性质,并补充治疗效果的数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
IPET-CT in inflammatory diseases of kidneys and bladder: diagnostic efficacy
Introduction. The incorporation of combined positron emission tomography-computed tomography (PET-CT) into clinical practice has significantly expanded the understanding of the pathogenesis of many diseases. Evidence-based data on the diagnostic efficacy in infectious and inflammatory diseases is increasing, making this imaging method very promising. Purpose of the study. To study the diagnostic efficacy of 18F-FDG PET-CT in various chronic inflammatory diseases of kidneys and bladder.Materials and methods. A retrospective study of the results of whole-body 18F-FDG PET-CT in 45 patients was carried out. Patients underwent an investigation at various times after surgical treatment of localized oncology of the anogenital zone at the T1N0M0 stage without the involvement of the genitourinary system. It was found that 24 patients had a history of chronic pyelonephritis and 21 patients had manifestations of radiation cystitis. Repeated PET/CT scans were performed after a course of therapy for inflammatory urological diseases to assess the treatment results of the underlying pathology.Results. The latent course of chronic renal failure was accompanied by a diffuse decrease in 18F-FDG metabolism in the renal parenchyma with its partial recovery after etiotropic therapy and urine sanitation. Hypermetabolism of 18F-FDG was detected in the bladder wall during manifestations of radiation cystitis, which was leveled during therapy and relief of urinary syndrome manifestations. Bacterial and radiation inflammation differed in molecular-cell responses to the pathogen, while the results of urinalysis, indicating the effectiveness of the treatment, coincided with the visual and digital indicators of the restoration of adequate energy metabolism in the studied tissues.Conclusions. Metabolism of 18F-FDG in the kidneys and bladder can objectively reflect the nature of inflammation and complement the data on the effectiveness of the treatment.
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