{"title":"纳米工程硅柱诱导间充质干细胞分化","authors":"L. Trabzon, M. Ramazanoglu, H. Kizil, S. Guvendik","doi":"10.1109/MECBME.2011.5752061","DOIUrl":null,"url":null,"abstract":"We successfully engineered Si nano-columns with different cross-sectional geometries by e-beam evaporation with an angle between source and substrate. The Si nano-columns were grown as pillars with square, triangle and linear cross sections in in-plane. Mesenchymal stem cells (MSCs) isolated from the bone marrow stroma of young adult rats were cultured on these different Si nanosurfaces. We found that the behaviour of MSCs highly depended on the geometry of nano-topography so that mesenchymal stem cells were differentiated and induced CaP precipitation on square-cross-sectional Si nano-columns without growth factor in the culture medium.","PeriodicalId":348448,"journal":{"name":"2011 1st Middle East Conference on Biomedical Engineering","volume":"2 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2011-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mesenchymal stem cell differentiation by nano-engineered Si columns\",\"authors\":\"L. Trabzon, M. Ramazanoglu, H. Kizil, S. Guvendik\",\"doi\":\"10.1109/MECBME.2011.5752061\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We successfully engineered Si nano-columns with different cross-sectional geometries by e-beam evaporation with an angle between source and substrate. The Si nano-columns were grown as pillars with square, triangle and linear cross sections in in-plane. Mesenchymal stem cells (MSCs) isolated from the bone marrow stroma of young adult rats were cultured on these different Si nanosurfaces. We found that the behaviour of MSCs highly depended on the geometry of nano-topography so that mesenchymal stem cells were differentiated and induced CaP precipitation on square-cross-sectional Si nano-columns without growth factor in the culture medium.\",\"PeriodicalId\":348448,\"journal\":{\"name\":\"2011 1st Middle East Conference on Biomedical Engineering\",\"volume\":\"2 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-04-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2011 1st Middle East Conference on Biomedical Engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/MECBME.2011.5752061\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2011 1st Middle East Conference on Biomedical Engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/MECBME.2011.5752061","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mesenchymal stem cell differentiation by nano-engineered Si columns
We successfully engineered Si nano-columns with different cross-sectional geometries by e-beam evaporation with an angle between source and substrate. The Si nano-columns were grown as pillars with square, triangle and linear cross sections in in-plane. Mesenchymal stem cells (MSCs) isolated from the bone marrow stroma of young adult rats were cultured on these different Si nanosurfaces. We found that the behaviour of MSCs highly depended on the geometry of nano-topography so that mesenchymal stem cells were differentiated and induced CaP precipitation on square-cross-sectional Si nano-columns without growth factor in the culture medium.
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