可变受体亲和力和组织敏感性。

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158850
M A Oriowo, R D Bevan, J A Bevan
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引用次数: 8

摘要

血管平滑肌对去甲肾上腺素(NE)的敏感性,通过体外收缩反应测量,在家兔的不同动脉和其他物种的同一血管中存在差异。NE对α 1-肾上腺素受体的亲和力变化与组织敏感性之间存在良好的相关性。这种变异是连续的,可能并不代表不同的受体亚型。从膜中溶解α - 1-肾上腺素受体改变了对特定配体的亲和力,而重建使其恢复。综上所述,这些结果表明,受体微环境中存在一个因子,能够调节NE的亲和力,从而调节组织对NE的敏感性。在一些血管中,受体数量也与α 1-肾上腺素受体对NE的亲和力显著相关。总的来说,受体数量的贡献远远小于对NE的亲和力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Variable receptor affinity and tissue sensitivity.

Vascular smooth muscle sensitivity to norepinephrine (NE), measured by contractile responses in vitro, varied in different arteries of the rabbit and also in the same vessels in other species. There was a good correlation between variation in the affinity of NE for the alpha 1-adrenoceptor and tissue sensitivity. The variation was continuous and probably not indicative of different receptor subtypes. Solubilization of alpha 1-adrenoceptors from the membrane changed the affinity for specific ligands while reconstitution restored it. Taken together, these results suggest the presence of a factor(s) within the receptor microenvironment capable of modulating affinity and hence tissue sensitivity to NE. In some blood vessels, receptor number was correlated significantly with affinity of the alpha 1-adrenoceptor for NE also. In general, the contribution of receptor number was considerably less than the affinity for NE.

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