[基于唾液中安替比林的消除率来评估小牛肝脏中的生物转化活性的尝试]。

Polskie archiwum weterynaryjne Pub Date : 1991-01-01
K Janus, S Baranow-Baranowski, D Jakubowska
{"title":"[基于唾液中安替比林的消除率来评估小牛肝脏中的生物转化活性的尝试]。","authors":"K Janus,&nbsp;S Baranow-Baranowski,&nbsp;D Jakubowska","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>In the test carried out on 10 calves-bulls of c.b. breed, aged 20-23 days, the usefulness of the rate of antipyrine elimination from saliva to the assessment of pharmacokinetics of this substance, and consequently to the assessment of the rate of liver biotransformation in these animals, was defined. It was stated that volume of antipyrine (phenazone) distribution, half-life period and the clearance of liver defined on the basis of determination of the changes of phenazone concentration in plasma and saliva are not significantly different. It was proved that in the neonatal period in calves the antipyrine fraction connected with plasma protein does not exceed 3 percent of general phenazone concentration in the plasma. On the grounds of the results of the antipyrine test carried out a second time on 5 calves, the frequent recurrence of the parameters of antipyrine kinetics in the tested animals was proved. The results of the experimental show that on the basis of determination of the phenazone concentration in saliva it is possible to define the biotransforming liver activity of the microsomal monoxygenase connected with cytochrome P-450 in calves and total water content in the organism.</p>","PeriodicalId":20364,"journal":{"name":"Polskie archiwum weterynaryjne","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[An attempt at assessment of biotransformation activity in calves' liver on the basis of the rate of antipyrine elimination from saliva].\",\"authors\":\"K Janus,&nbsp;S Baranow-Baranowski,&nbsp;D Jakubowska\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In the test carried out on 10 calves-bulls of c.b. breed, aged 20-23 days, the usefulness of the rate of antipyrine elimination from saliva to the assessment of pharmacokinetics of this substance, and consequently to the assessment of the rate of liver biotransformation in these animals, was defined. It was stated that volume of antipyrine (phenazone) distribution, half-life period and the clearance of liver defined on the basis of determination of the changes of phenazone concentration in plasma and saliva are not significantly different. It was proved that in the neonatal period in calves the antipyrine fraction connected with plasma protein does not exceed 3 percent of general phenazone concentration in the plasma. On the grounds of the results of the antipyrine test carried out a second time on 5 calves, the frequent recurrence of the parameters of antipyrine kinetics in the tested animals was proved. The results of the experimental show that on the basis of determination of the phenazone concentration in saliva it is possible to define the biotransforming liver activity of the microsomal monoxygenase connected with cytochrome P-450 in calves and total water content in the organism.</p>\",\"PeriodicalId\":20364,\"journal\":{\"name\":\"Polskie archiwum weterynaryjne\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Polskie archiwum weterynaryjne\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polskie archiwum weterynaryjne","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

在对10只20-23日龄的c.b.品种的小牛-公牛进行的试验中,定义了唾液中安替比林的消除率对该物质的药代动力学评估的有用性,从而对这些动物肝脏生物转化率的评估。通过测定血浆和唾液中非那酮浓度的变化,确定安替比林(非那酮)的体积分布、半衰期和肝脏清除率无显著差异。结果表明,在犊牛新生儿期,与血浆蛋白相关的安替比林分数不超过血浆中一般非那酮浓度的3%。根据对5头小牛进行第二次安替比林试验的结果,证明了安替比林动力学参数在试验动物中的频繁复发。实验结果表明,在测定唾液中非那酮浓度的基础上,可以确定犊牛体内与细胞色素P-450相关的微粒体单加氧酶的生物转化肝脏活性和生物体的总含水量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[An attempt at assessment of biotransformation activity in calves' liver on the basis of the rate of antipyrine elimination from saliva].

In the test carried out on 10 calves-bulls of c.b. breed, aged 20-23 days, the usefulness of the rate of antipyrine elimination from saliva to the assessment of pharmacokinetics of this substance, and consequently to the assessment of the rate of liver biotransformation in these animals, was defined. It was stated that volume of antipyrine (phenazone) distribution, half-life period and the clearance of liver defined on the basis of determination of the changes of phenazone concentration in plasma and saliva are not significantly different. It was proved that in the neonatal period in calves the antipyrine fraction connected with plasma protein does not exceed 3 percent of general phenazone concentration in the plasma. On the grounds of the results of the antipyrine test carried out a second time on 5 calves, the frequent recurrence of the parameters of antipyrine kinetics in the tested animals was proved. The results of the experimental show that on the basis of determination of the phenazone concentration in saliva it is possible to define the biotransforming liver activity of the microsomal monoxygenase connected with cytochrome P-450 in calves and total water content in the organism.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信