n -乙酰muramyl- l- alanyl- d -异谷氨酰胺和n -乙酰氨基葡萄糖-(β 1----4)- n -乙酰muramyl- l- alanyl- d -异谷氨酰胺免疫调节特性的研究。

Biomedical science Pub Date : 1991-01-01

I M Dozmorov, I I Kuzin, N I Lutsan, G V Lutsenko, A L Prokhorova, A M Sapozhnikov, T M Andronova, V T Ivanov

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引用次数: 0

摘要

两种合成的muramylpeptides (MP)，一种muramyldipeptide和一种glucosaminyl- muramyldipeptide，已经被比较并发现在它们的作用中表现出许多共同的特征。此外，还详细研究了低浓度和高浓度MP对体外原发性体液免疫反应的不同影响。高浓度的MP增加了诱导t抑制细胞的频率，而低浓度的MP通过增强辅助细胞的抗原呈递功能和增加诱导t辅助细胞的频率来刺激初级免疫反应。

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Study of immunomodulatory properties of N-acetylmuramyl-L-alanyl-D-isoglutamine and N-acetylglucosaminyl-(beta 1----4)-N-acetylmuramyl-L-alanyl-D-isoglutamine.

The immunomodulatory activities of two synthetic muramylpeptides (MP), a muramyl dipeptide and a glucosaminyl-muramyl dipeptide, have been compared and have been found to exhibit many common features in their effects. In addition, the differential effects of low and high concentrations of MP on the primary humoral immune response in vitro were examined in detail. At high concentrations MP augmented the frequency of induced T-suppressor cells, while at low concentrations the primary immune response was stimulated by enhancement of the antigen-presenting function of accessory cells and by increasing the frequency of induced T-helper cells.

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Biomedical science

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