异质mRNA1273增强疫苗接种后新发mpo相关中枢神经系统血管炎1例

Y. Jeong, Sung‐Jo Bang, G. Kim, Jae Ho Jeon, Gi Ryeong Oh, C. Chung, Hyung-Kuk Park
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引用次数: 0

摘要

冠状病毒病-19 (COVID-19)大流行不可避免地导致了缺乏足够安全性的疫苗的快速推出。特别是,已知严重急性呼吸综合征冠状病毒2感染可诱导过度免疫反应,如中性粒细胞释放蛋白酶-3和髓过氧化物酶(MPO)。这种过度反应的免疫反应导致了对COVID-19疫苗接种后自身免疫性疾病发展的担忧。我们报告了异质mRNA1273 - COVID-19加强疫苗接种后累及中枢神经系统的新发mpo相关系统性血管炎病例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Case of de novo MPO-associated Central Nervous System Vasculitis Following Heterogeneous mRNA1273 COVID-19 Booster Vaccination
The coronavirus disease-19 (COVID-19) pandemic leaded to inevitable expeditious vaccine rollout without sufficient safety profile. Especially, severe acute respiratory syndrome coronavirus 2 infection has known to induce overreacted immune responses such as releasing of proteinase-3 and myeloperoxidase (MPO) by neutrophil. This overreacted immune response leads to the concern of the development of autoimmune diseases after COVID-19 vaccination. We report the case of de novo MPO-associated systemic vasculitis involving central nervous system following heterogeneous mRNA1273 COVID-19 booster vaccination.
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