{"title":"三羟基肌苷的合成","authors":"E. S. Deusova, M. Khancheuski, E. Kvasyuk","doi":"10.46646/sakh-2021-2-41-44","DOIUrl":null,"url":null,"abstract":"Nucleoside derivatives with broken sugar moiety like dialdehydes or trioles have unusual structures and are called seco-nucleosides. They have different types of biological activity which till this time have not been studied enough. It is a result of the high reactivity of aldehydes and hydroxyl groups and the unusual structure of compounds. This article presents two approaches for the synthesis of trihydroxy-inosine from inosine. It was shown that the method for oxidation of diol groups of ribonucleosides using the ion exchange resin in IO4-former has preferences to the method which used NaIO4 as a reagent.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SYNTHESIS OF TRIHYDROXY-INOSINE\",\"authors\":\"E. S. Deusova, M. Khancheuski, E. Kvasyuk\",\"doi\":\"10.46646/sakh-2021-2-41-44\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Nucleoside derivatives with broken sugar moiety like dialdehydes or trioles have unusual structures and are called seco-nucleosides. They have different types of biological activity which till this time have not been studied enough. It is a result of the high reactivity of aldehydes and hydroxyl groups and the unusual structure of compounds. This article presents two approaches for the synthesis of trihydroxy-inosine from inosine. It was shown that the method for oxidation of diol groups of ribonucleosides using the ion exchange resin in IO4-former has preferences to the method which used NaIO4 as a reagent.\",\"PeriodicalId\":385455,\"journal\":{\"name\":\"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46646/sakh-2021-2-41-44\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46646/sakh-2021-2-41-44","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Nucleoside derivatives with broken sugar moiety like dialdehydes or trioles have unusual structures and are called seco-nucleosides. They have different types of biological activity which till this time have not been studied enough. It is a result of the high reactivity of aldehydes and hydroxyl groups and the unusual structure of compounds. This article presents two approaches for the synthesis of trihydroxy-inosine from inosine. It was shown that the method for oxidation of diol groups of ribonucleosides using the ion exchange resin in IO4-former has preferences to the method which used NaIO4 as a reagent.
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