用于肿瘤成像的分子光学探针

Digest of the LEOS Summer Topical Meetings Biophotonics/Optical Interconnects and VLSI Photonics/WBM Microcavities, 2004. Pub Date : 2004-06-28 DOI:10.1109/LEOSST.2004.1338660

S. Achilefu, S. Bloch, Y. Ye, Z. Zhang, R. Dorshow, K. Liang

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引用次数: 0

摘要

生物医学光学方法提供了明显新的诊断能力，同时补充了传统的成像方式。为了有效，分子探针应该产生可检测的、可量化的和可识别的信号，以响应光吸收或生物激活。目前，荧光素、吲哚菁绿(ICG)和荧光光敏剂被广泛用作肿瘤体内成像的光学分子探针，可能是由于它们已建立的光物理特性和在人体中的安全性。

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Molecular optical probes for imaging tumors

Biomedical optical methods provide distinctly new diagnostic capabilities while complementing conventional imaging modalities. To be effective, the molecular probes should produce detectable, quantifiable and discernable signals in response to light absorption or biological activation. Presently, fluorescein, indocyanine green (ICG) and fluorescent photosensitizers are widely used as optical molecular probes for in vivo imaging of tumors, possibly due to their established photophysical properties and safety profile in humans.

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Digest of the LEOS Summer Topical Meetings Biophotonics/Optical Interconnects and VLSI Photonics/WBM Microcavities, 2004.

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