[阿片系统水平上胆碱溶解剂和胆碱模拟剂的生化拮抗作用]。

Farmakologiia i toksikologiia Pub Date : 1991-11-01
V A Zhila, G N Gatsenko, L A Gromov
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引用次数: 0

摘要

用放射免疫法对白化病大鼠进行的实验表明,m -胆碱阻滞剂(阿托品、阿米齐、glypine)可降低脑和血液中脑啡肽和-内啡肽的含量,而m -胆碱模拟剂(槟油碱、尼古丁、毒豆碱)可增加阿片样神经肽的含量。这表明,在阿片系统水平上,胆碱阻滞剂和胆碱模拟剂之间不仅存在功能上的拮抗,而且存在生化上的拮抗。此外,还提出了胆碱阻滞剂和胆碱模拟剂的毒性作用主要与阿片神经肽的代谢和功能紊乱有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The biochemical antagonism of cholinolytics and cholinomimetics at the level of the opiate system].

The experiments on albino rats with the use of the radioimmunoassay showed that M-cholinoblockers (atropine, amizil, glypine) decrease the contents of enkephalins and beta-endorphin in the brain and blood whereas M-cholinomimetics (arecoline, nicotine, physostigmine) increase the level of opioid neuropeptides. This suggested that between cholinoblockers and cholinomimetics there is not only functional but also biochemical antagonism at the level of the opiate system. In addition, the statement is developed that toxic effects of cholinoblockers and cholinomimetics are largely related to disturbances of metabolism and function of opioid neuropeptides.

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