[兔肝部分切除和肝缺血后各器官内药物和内源性底物的代谢]。

Farmakologiia i toksikologiia Pub Date : 1991-11-01
M E Krakovskiĭ, A Kh Ashirmetov
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引用次数: 0

摘要

短句来源本实验采用氧吸收率极谱法测定20只公兔肝部分切除肝缺血4 d后,肝脏、肾脏、小肠黏膜和肺分离微粒体对己烯醛、阿米比林、非那西汀、普罗美多、丙酮、氢化可的松、睾酮和前列腺素E2的代谢强度。结果发现,两种肝损伤模型均出现阿米比林、己烯醛、非那西丁代谢减少,氢化可的松和前列腺素E2代谢增加。在肺中,可以观察到肝切除术后所研究药物的代谢增加及其对肝缺血的抑制作用。在肾和肠两种类型的肝损伤中,观察到药物代谢具有代偿性的反向变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The metabolism of drugs and endogenous substrates in the organs of rabbits following partial hepatectomy and liver ischemia].

The intensity of metabolism of hexenal, amidopyrine, phenacetin, promedol, acetone, hydrocortisone, testosterone and prostaglandin E2 by the isolated microsomes of the liver, kidneys, small intestinal mucosa and lungs was studied polarographically by the rate of oxygen absorption in experiments on 20 male rabbits four days following partial hepatectomy and liver ischemia. It was found that with both models of the liver damage there was observed a decrease of metabolism of amidopyrine, hexenal, phenacetin and an increase of metabolism of hydrocortisone and prostaglandin E2. In the lungs one could observe an increase of metabolism of the studies drugs following hepatectomy and its inhibition in liver ischemia. In the kidneys and intestine in both types of the liver damage contradirected changes in drug metabolism being of the compensatory character were observed.

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