Neuromodulators for Functional Dyspepsia-A Gut-Brain Interaction Disorder: Uptodate Clinical Practice

Functional dyspepsia significantly affects the quality of life and is a major cause of economic burden on both the patient and society. Adherence to international guidelines for the management of dyspepsia is crucial to avoid unnecessary procedures and medications. However, many countries have not assessed functional dyspepsia symptoms as defined by the ROME IV diagnostic criteria. Current clinical practices differ among countries, especially regarding the use of neuromodulators despite the recommended use of these drugs according to recent guidelines. There are also clinical differences between FD variants and different treatment regimens.