[1,3-二苯基吡唑-4-羧酸的金刚烷酰胺对肝脏细胞色素P-450系统的影响]。

Farmakologiia i toksikologiia Pub Date : 1991-07-01

T G Khlopushina, A V Krinskaia

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引用次数: 0

摘要

研究了1,3-二苯基吡唑-4-碳酸类金刚烷酰胺对肝微粒体单加氧酶系统的影响。发现1,3-二苯基吡唑-5-甲基-4-羧酸，n -甲基- n -(金刚烷-1-il)酰胺对肝细胞色素P-450有明显的诱导作用。由于肝细胞色素P-450的诱导作用，该化合物降低了小鼠延迟型超敏反应程度的40%。

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[The effect of the adamantylamides of 1,3-diphenylpyrazole-4-carboxylic acids on the cytochrome P-450 system of the liver].

The effect of adamanthylamides of 1,3-diphenylptrazol-4-carbonic acids on the system of the liver microsomal monoxygenases was studied. A potent induction of the liver cytochrome P-450 by 1,3-diphenylpyrazol-5-methyl-4-carbonic acid, N-methyl-N-(adamant-1-il)amide was found. As a consequence of the induction of the liver cytochrome P-450, the compound reduced by 40% the degree of the delayed type hypersensitivity in mice.

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Farmakologiia i toksikologiia

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