{"title":"吲哚啉酮衍生物对血浆止血的作用","authors":"VV Bykov, Serebrov VYu, Ev Udut, VV Udut","doi":"10.31038/jppr.2019222","DOIUrl":null,"url":null,"abstract":"The action of a new pharmaceutical substance of indolinone series, an sGC inducer with antiplatelet activity, on rat blood plasma hemostasis was studied. It was shown that the antiplatelet substance after single oral administration to rats considerably increases thrombin time after 3 hours (24.5 versus 17.3 in control, р <0.05). Other plasma hemostasis parameters were unchanged.","PeriodicalId":285318,"journal":{"name":"Journal of Pharmacology & Pharmaceutical Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Action of an Indolinone Derivative on Plasma Hemostasis\",\"authors\":\"VV Bykov, Serebrov VYu, Ev Udut, VV Udut\",\"doi\":\"10.31038/jppr.2019222\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The action of a new pharmaceutical substance of indolinone series, an sGC inducer with antiplatelet activity, on rat blood plasma hemostasis was studied. It was shown that the antiplatelet substance after single oral administration to rats considerably increases thrombin time after 3 hours (24.5 versus 17.3 in control, р <0.05). Other plasma hemostasis parameters were unchanged.\",\"PeriodicalId\":285318,\"journal\":{\"name\":\"Journal of Pharmacology & Pharmaceutical Research\",\"volume\":\"16 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-04-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmacology & Pharmaceutical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31038/jppr.2019222\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmacology & Pharmaceutical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31038/jppr.2019222","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Action of an Indolinone Derivative on Plasma Hemostasis
The action of a new pharmaceutical substance of indolinone series, an sGC inducer with antiplatelet activity, on rat blood plasma hemostasis was studied. It was shown that the antiplatelet substance after single oral administration to rats considerably increases thrombin time after 3 hours (24.5 versus 17.3 in control, р <0.05). Other plasma hemostasis parameters were unchanged.
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