4 ' -碘-4 ' -脱氧阿霉素的早期心脏毒性

Fabrizio Villani, Milena Galimberti, Roberto Comazzi
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引用次数: 9

摘要

对35例晚期恶性肿瘤患者静脉给予4′-碘-4′-脱氧阿霉素。剂量依次递增:2、4、6、7、10、14、19、26、52、70、80和90 mg/m2。通过动态心电图监测和超声心动图评估心肌功能。注药后24小时内可归因于该药的心律失常发生率分别为14.3%(室上)和10.6%(室上)。注射药物后24 h和21 d超声心动图心功能指标无变化。数据表明,4 ' -碘-4 ' -脱氧阿霉素没有明显的急性心脏毒性作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early cardiac toxicity of 4′-iodo-4′-deoxydoxorubicin

4′-iodo-4′-deoxydoxorubicin was administered intravenously to 35 patients with advanced malignant neoplasms. The doses were escalated as follows: 2, 4, 6, 7, 10, 14, 19, 26, 52, 70, 80 and 90 mg/m2. Myocardial function was assessed by Holter monitoring and echocardiography. The prevalence of arrhythmias that could be attributed to the drug in the 24 h following infusion was 14.3% (supraventricular) and 10.6% (ventricular). Echocardiographic heart function variables were unchanged at 24 h and 21 days from drug injection. The data indicate the absence of significant, acute cardiotoxic effects of 4′-iodo-4′-deoxydoxorubicin.

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