胰岛素和胰岛素受体在脂肪组织中的作用

Il Diabete Pub Date : 2023-07-10 DOI:10.30682/ildia2302g

Valentina Annamaria Genchi, Celeste Lauriola, Angelo Cignarelli, F. Giorgino

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引用次数: 0

摘要

胰岛素通过激活胰岛素受体(INSR)来调节全身能量和脂质代谢，包括两种亚型:INSR- a在低分化细胞中表达，具有显著的有丝分裂作用;INSR-B主要在具有明显代谢特性的成人组织中表达。众所周知，INSR-A/INSR-B比值的组织特异性变化可能有利于代谢异常的发展。在此，我们研究了胰岛素/INSR信号在脂肪组织生理学的几个方面的调节中的作用，以及胰岛素模拟物对肥胖的影响。

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Ruolo dell’insulina e del recettore insulinico nel tessuto adiposo

Insulin regulates whole-body energy and lipid metabolism by activating the insulin receptor (INSR) consisting in two isoforms: INSR-A expressed in less-differentiated cells with prominent mitogenic effect; INSR-B mostly expressed in adult tissues with pronounced metabolic properties. It is well known that tissue-specific variation in INSR-A/INSR-B ratio may favour the development of metabolic abnormalities. Herein, we examine the role of insulin/INSR signalling in the regulation of several aspects of adipose tissue physiology and the effects of insulin mimetics on adiposity.

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Il Diabete

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