fg -核孔蛋白的液态模拟了核孔复合物的渗透屏障特性

The Journal of Cell Biology Pub Date : 2019-11-13 DOI:10.1083/jcb.201907157

G. Celetti, G. Paci, Joana Caria, V. Vandelinder, G. Bachand, E. Lemke

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引用次数: 82

摘要

核孔复合物在体内形成通透性屏障，调节核胞质运输。在这里，作者提出了一种将核孔蛋白的液-液快速分离与直接光学询问耦合在一起的微流体装置。新形成的液态核孔蛋白液滴模拟npc的渗透屏障特性。

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The liquid state of FG-nucleoporins mimics permeability barrier properties of nuclear pore complexes

Nuclear pore complexes form a permeability barrier in vivo that regulates nucleocytoplasmic transport. Here, the authors present a microfluidic device that couples rapid liquid–liquid phase separation of nucleoporins with direct optical interrogation. Freshly formed liquid nucleoporin droplets mimic permeability barrier properties of NPCs.

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The Journal of Cell Biology

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