Factors Associated with Lymphovascular Invasion in Colorectal Adenocarcinoma at Dr. Cipto Mangunkusumo General Hospital, Jakarta: A Preliminary Report

Background: Lymph node metastasis is a prognostic factor in colorectal adenocarcinoma. Besides, lymphovascular invasion is one of the factors to indicate the lymph node metastasis. This study aimed to investigate factors associated with lymphovascular invasion in our hospital. Methods: This preliminary report was a cross−sectional study of patients with colorectal adenocarcinoma in Cipto Manungkusumo General Hospital, Jakarta, Indonesia between 2012 and 2016. Our focus of interest was the association between lymphovascular invasion and variables of patient’s characteristics, including age, gender, location of the tumor, tumor differentiation, pathological stage of tumor infiltration, and lymph node metastasis. Results: We found 70% of the 68 subjects had lymphovascular invasions. Among all the variables analyzed for association with lymphovascular invasion, there is no factor with significant association. However, lymph node metastasis was found to have significant association with lymphovascular invasion (odd ratio [OR] = 6.69, 95% confidence interval [CI] = 2.09–21.38, p−value =0.001). Conclusion: Although lymphovascular invasion was significantly associated with lymph node metastasis in colorectal adenocarcinoma, there is no factor significantly associated with lymphovascular invasion in this study.