{"title":"线粒体丙酮酸载体1和2异源二聚体，植物和人类复合物模型:结构和转运体结合特性的比较","authors":"Jason L. Dugan, Allen K. Bourdon, C. Phelix","doi":"10.4018/IJKDB.2017070102","DOIUrl":null,"url":null,"abstract":"Theplantandhumanmitochondrialpyruvatecarrier(MPC)hadbeenstudiedinthe1970s-1990s providingmanypredictionsonfunctionalproteinstructureandmechanismsofsubstratebinding.Genes forhumanandplantMPChavebeenidentified,butnocrystalstructurehasyetbeenregisteredor depositedinaproteindatabank.Thisreportdescribesresultsforcomparisonsofstructureforhuman andplantMPC1/2heterodimerhomologymodels.Keycysteineresiduesareidentifiedforpyruvate andblockerbindingandformationofthiohemiacetalorMichaeladditionbonds.Evidenceisprovided foranalternatingaccessmodelinhuman,mouseear-cress,castorandcommonbeans,andcorn. KeywoRDS Arabidopsis Thaliana, Homo Sapien, In Silico, Phaseolus Vulgaris, Protein Homology, Protein Protein Docking, Pyruvate Docking, Ricinus Communis, Zea Mays","PeriodicalId":160270,"journal":{"name":"Int. J. Knowl. Discov. Bioinform.","volume":"14 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Mitochondrial Pyruvate Carrier 1 and 2 Heterodimer, In Silico, Models of Plant and Human Complexes: A Comparison of Structure and Transporter Binding Properties\",\"authors\":\"Jason L. Dugan, Allen K. Bourdon, C. Phelix\",\"doi\":\"10.4018/IJKDB.2017070102\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Theplantandhumanmitochondrialpyruvatecarrier(MPC)hadbeenstudiedinthe1970s-1990s providingmanypredictionsonfunctionalproteinstructureandmechanismsofsubstratebinding.Genes forhumanandplantMPChavebeenidentified,butnocrystalstructurehasyetbeenregisteredor depositedinaproteindatabank.Thisreportdescribesresultsforcomparisonsofstructureforhuman andplantMPC1/2heterodimerhomologymodels.Keycysteineresiduesareidentifiedforpyruvate andblockerbindingandformationofthiohemiacetalorMichaeladditionbonds.Evidenceisprovided foranalternatingaccessmodelinhuman,mouseear-cress,castorandcommonbeans,andcorn. KeywoRDS Arabidopsis Thaliana, Homo Sapien, In Silico, Phaseolus Vulgaris, Protein Homology, Protein Protein Docking, Pyruvate Docking, Ricinus Communis, Zea Mays\",\"PeriodicalId\":160270,\"journal\":{\"name\":\"Int. J. Knowl. Discov. Bioinform.\",\"volume\":\"14 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Int. J. Knowl. Discov. Bioinform.\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4018/IJKDB.2017070102\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Int. J. Knowl. Discov. Bioinform.","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4018/IJKDB.2017070102","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mitochondrial Pyruvate Carrier 1 and 2 Heterodimer, In Silico, Models of Plant and Human Complexes: A Comparison of Structure and Transporter Binding Properties
Theplantandhumanmitochondrialpyruvatecarrier(MPC)hadbeenstudiedinthe1970s-1990s providingmanypredictionsonfunctionalproteinstructureandmechanismsofsubstratebinding.Genes forhumanandplantMPChavebeenidentified,butnocrystalstructurehasyetbeenregisteredor depositedinaproteindatabank.Thisreportdescribesresultsforcomparisonsofstructureforhuman andplantMPC1/2heterodimerhomologymodels.Keycysteineresiduesareidentifiedforpyruvate andblockerbindingandformationofthiohemiacetalorMichaeladditionbonds.Evidenceisprovided foranalternatingaccessmodelinhuman,mouseear-cress,castorandcommonbeans,andcorn. KeywoRDS Arabidopsis Thaliana, Homo Sapien, In Silico, Phaseolus Vulgaris, Protein Homology, Protein Protein Docking, Pyruvate Docking, Ricinus Communis, Zea Mays
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