中枢神经系统P物质在自发性高血压大鼠发病中的作用。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

J Chen, J Gao, H Xue, Y Liu, C Xu

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摘要

通过比较P物质(SP)在Wistar-Kyoto (WKY)大鼠和自发性高血压大鼠(SHR)血管舒缩张力中枢调节中的作用，我们发现:SHR大鼠下丘脑、延髓吻侧腹面(RVM)和胸脊髓中外侧细胞柱(IML)的SP样免疫反应性(SPLI)程度显著高于WKY大鼠;鞘内注射SP受体拮抗剂D-Pro2、D-Phe7、D-Trp9-SP (D-SP)可降低SHR和WKY大鼠的平均血压(MBP)。提示SP可能参与了高血压的发病机制和正常血压的调节。

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The role of substance P of the central nervous system in the pathogenesis of spontaneously hypertensive rats.

In comparing the involvement of substance P (SP) in the central regulation of vasomotor tone in Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR), we found that: the degree of SP-like immunoreactivity (SPLI) in the hypothalamus, rostral ventral surface of the medulla oblongata (RVM) and intermediolateral cell column (IML) of the thoracic spinal cord of SHR rats was significantly higher than in WKY rats; intrathecal injection (ith) of SP receptor antagonist D-Pro2, D-Phe7, D-Trp9-SP (D-SP) caused a decrease of mean blood pressure (MBP) in both SHR and WKY rats. These results indicate that SP might participate in the pathogenesis of hypertension and the regulation of normal blood pressure.

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Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao

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