造血细胞中src相关酪氨酸蛋白激酶的信号成分。

IF 3.5 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
E Eiseman, J B Bolen
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引用次数: 0

摘要

src相关的酪氨酸蛋白激酶被认为参与控制细胞生长的信号转导,以及在完全分化的非增殖细胞中发挥特殊功能。其中一种激酶p56lck与T淋巴细胞中CD4和CD8细胞表面受体的关联提供了一个模型系统,通过该模型系统,src相关酪氨酸激酶的第一个功能已经被定义。这些在T淋巴细胞中的初步观察结果促使研究人员探索src相关酪氨酸激酶与其他受体复合物的潜在关联。目前正在寻找证据表明这些激酶可能通过B淋巴细胞和嗜碱性细胞中发现的多种细胞受体参与介导信号事件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
src-related tyrosine protein kinases as signaling components in hematopoietic cells.

The src-related tyrosine protein kinases are thought to be involved in the transduction of signals controlling cell growth as well as in specialized functions in fully differentiated, nonproliferating cells. The association of one of these kinases, p56lck, with the CD4 and CD8 cell-surface receptors in T lymphocytes has provided a model system through which the first function for a src-related tyrosine kinase has been defined. These initial observations in T lymphocytes have led investigators to explore the potential association of the src-related tyrosine kinases with other receptor complexes. Evidence that these kinases may be involved in mediating signaling events through such diverse cellular receptors as those found in B lymphocytes and basophils is currently being pursued.

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